FDG-PET positive pilomatrixoma--reconsidering multicentricity in Langerhans cell histiocytosis

Nucl Med Rev Cent East Eur. 2014;17(2):94-6. doi: 10.5603/NMR.2014.0024.


We report a case of a woman who underwent a curative resection of an upper jaw tumor histologically verified as eosinophilic granuloma. To exclude possible multiorgan involvement, PET/CT imaging was performed and revealed a metabolically active, partially calcified lesion located on the chest wall surface and clinically corresponding to a gradually developing, round, subcutaneous infiltrate with erythematous overlying skin. After complete extirpation, the pathological finding was consistent with pilomatrixoma surprisingly, thus dismissing the suspected diagnosis of multi-system Langerhans cell histiocytosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Female
  • Hair Diseases / diagnostic imaging*
  • Histiocytosis, Langerhans-Cell / diagnostic imaging*
  • Humans
  • Pilomatrixoma / diagnostic imaging*
  • Positron-Emission Tomography*
  • Radiography
  • Skin Neoplasms / diagnostic imaging*