From foe to friend: using animal toxins to investigate ion channel function

J Mol Biol. 2015 Jan 16;427(1):158-175. doi: 10.1016/j.jmb.2014.07.027. Epub 2014 Aug 1.


Ion channels are vital contributors to cellular communication in a wide range of organisms, a distinct feature that renders this ubiquitous family of membrane-spanning proteins a prime target for toxins found in animal venom. For many years, the unique properties of these naturally occurring molecules have enabled researchers to probe the structural and functional features of ion channels and to define their physiological roles in normal and diseased tissues. To illustrate their considerable impact on the ion channel field, this review will highlight fundamental insights into toxin-channel interactions and recently developed toxin screening methods and practical applications of engineered toxins.

Keywords: animal toxin; screening approaches; toxin engineering; transient receptor potential channel; voltage-gated ion channel.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channel Gating / drug effects*
  • Ion Channels / drug effects*
  • Ion Channels / physiology*
  • Signal Transduction / drug effects
  • Toxins, Biological / pharmacology*


  • Ion Channels
  • Toxins, Biological