Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis

Public Health Nutr. 2015 May;18(7):1282-91. doi: 10.1017/S1368980014001438. Epub 2014 Aug 4.


Objective: We aimed to use the meta-analysis method to assess the relationship between coffee drinking and all-cause mortality.

Design: Categorical and dose-response meta-analyses were conducted using random-effects models.

Setting: We systematically searched and identified eligible literature in the PubMed and Scopus databases.

Subjects: Seventeen studies including 1 054 571 participants and 131 212 death events from all causes were included in the present study.

Results: Seventeen studies were included and evaluated in the meta-analysis. A U-shaped dose-response relationship was found between coffee consumption and all-cause mortality (P for non-linearity <0.001). Compared with non/occasional coffee drinkers, the relative risks for all-cause mortality were 0.89 (95 % CI 0.85, 0.93) for 1-<3 cups/d, 0.87 (95 % CI 0.83, 0.91) for 3-<5 cups/d and 0.90 (95 % CI 0.87, 0.94) for ≥5 cups/d, and the relationship was more marked in females than in males.

Conclusions: The present meta-analysis of prospective cohort studies indicated that light to moderate coffee intake is associated with a reduced risk of death from all causes, particularly in women.

Keywords: Prospective cohort study.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Coffee / adverse effects*
  • Cohort Studies
  • Diet / adverse effects*
  • Female
  • Functional Food / adverse effects*
  • Health Promotion*
  • Health Status*
  • Humans
  • Male
  • Middle Aged
  • Mortality
  • Prospective Studies
  • Sex Factors


  • Coffee