Molecular markers for breast cancer diagnosis, prognosis and targeted therapy

J Surg Oncol. 2015 Jan;111(1):81-90. doi: 10.1002/jso.23732. Epub 2014 Aug 5.


Precision medicine involves understanding the molecular drivers unique to an individual patient's cancer so that specific factors may be targeted with the goal of improved patient outcomes. The purpose of this article is to review standard of care and research grade (non-standard of care) biomarkers in breast cancer that may be useful for diagnosis, prognosis and targeted therapy.

Keywords: biomarker; breast cancer; molecular marker; personalized medicine; precision medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Biomarkers, Tumor / genetics*
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / therapy
  • Female
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Humans
  • Molecular Targeted Therapy*
  • Prognosis


  • Antineoplastic Agents
  • Biomarkers, Tumor