Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus

Respir Res. 2014 Aug 5;15(1):85. doi: 10.1186/s12931-014-0085-2.


Surfactant protein A has been shown to enhance opsonization and clearance of Staphylococcus aureus in vitro. Here, the phagocytosis of alveolar S. aureus was investigated in vivo using intravital microscopy. Fluorescence labelled S. aureus Newman cells were intratracheally administered to anesthetized mice and the alveolar surface was observed for fifteen minutes. Confirming previously reported in vitro data, surfactant protein A-deficient mice showed a significantly reduced uptake of bacteria compared to wild-type mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Lung / chemistry
  • Lung / metabolism*
  • Lung / microbiology
  • Macrophages, Alveolar / chemistry
  • Macrophages, Alveolar / metabolism*
  • Macrophages, Alveolar / microbiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phagocytosis / physiology*
  • Pulmonary Surfactant-Associated Protein A / physiology*
  • Staphylococcus aureus / chemistry
  • Staphylococcus aureus / metabolism*


  • Pulmonary Surfactant-Associated Protein A