Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 289 (6), 1045-60

Whole-genome Duplication in Teleost Fishes and Its Evolutionary Consequences

Affiliations
Review

Whole-genome Duplication in Teleost Fishes and Its Evolutionary Consequences

Stella M K Glasauer et al. Mol Genet Genomics.

Abstract

Whole-genome duplication (WGD) events have shaped the history of many evolutionary lineages. One such duplication has been implicated in the evolution of teleost fishes, by far the most species-rich vertebrate clade. After initial controversy, there is now solid evidence that such event took place in the common ancestor of all extant teleosts. It is termed teleost-specific (TS) WGD. After WGD, duplicate genes have different fates. The most likely outcome is non-functionalization of one duplicate gene due to the lack of selective constraint on preserving both. Mechanisms that act on preservation of duplicates are subfunctionalization (partitioning of ancestral gene functions on the duplicates), neofunctionalization (assigning a novel function to one of the duplicates) and dosage selection (preserving genes to maintain dosage balance between interconnected components). Since the frequency of these mechanisms is influenced by the genes' properties, there are over-retained classes of genes, such as highly expressed ones and genes involved in neural function. The consequences of the TS-WGD, especially its impact on the massive radiation of teleosts, have been matter of controversial debate. It is evident that gene duplications are crucial for generating complexity and that WGDs provide large amounts of raw material for evolutionary adaptation and innovation. However, it is less clear whether the TS-WGD is directly linked to the evolutionary success of teleosts and their radiation. Recent studies let us conclude that TS-WGD has been important in generating teleost complexity, but that more recent ecological adaptations only marginally related to TS-WGD might have even contributed more to diversification. It is likely, however, that TS-WGD provided teleosts with diversification potential that can become effective much later, such as during phases of environmental change.

Similar articles

See all similar articles

Cited by 139 PubMed Central articles

See all "Cited by" articles

References

    1. Genetics. 1999 Apr;151(4):1531-45 - PubMed
    1. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5454-9 - PubMed
    1. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3812-20 - PubMed
    1. Genome Res. 2005 Sep;15(9):1307-14 - PubMed
    1. J Exp Zool B Mol Dev Evol. 2007 Dec 15;308(6):730-43 - PubMed

Publication types

LinkOut - more resources

Feedback