Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis

Antimicrob Agents Chemother. 2014 Oct;58(10):6297-301. doi: 10.1128/AAC.02784-14. Epub 2014 Aug 4.


We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted a background antitubercular regimen (BR) with or without linezolid (LZD). At the 4th week, the LZD-BR group achieved a faster and higher percentage of Glasgow coma scale recovery and temperature recovery, a higher cerebrospinal fluid (CSF)/blood glucose ratio, and lower CSF white blood cell counts than did the BR group. Short-term linezolid supplementation may be a more effective treatment for life-threatening TBM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / therapeutic use*
  • Adult
  • Antitubercular Agents / therapeutic use*
  • Female
  • Humans
  • Linezolid
  • Male
  • Middle Aged
  • Oxazolidinones / therapeutic use*
  • Retrospective Studies
  • Treatment Outcome
  • Tuberculosis, Meningeal / drug therapy*


  • Acetamides
  • Antitubercular Agents
  • Oxazolidinones
  • Linezolid