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. 2014:2014:841496.
doi: 10.1155/2014/841496. Epub 2014 Jun 30.

Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats

Bao-Zhong Diao  1 , Wei-Rong Jin  1 , Xue-Jing Yu  2
Affiliations

Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats

Bao-Zhong Diao et al. Evid Based Complement Alternat Med. 2014.

Abstract

The present study aimed to evaluate the therapeutic effects of polysaccharides from Inonotus obliquus (PIO) on streptozotocin- (STZ-) induced diabetic symptoms and their potential mechanisms. The effect of PIO on body weight, blood glucose, damaged pancreatic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. The results show that administration of PIO can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with PIO 6 weeks later. Therefore, we may assume that PIO is effective in the protection of STZ-induced diabetic rats and PIO may be of use as antihyperglycemic agent.

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Figures

Figure 1
Figure 1
Effect of PIO administration on diabetic rats' body weight. Values represent the mean ± SEM. *P < 0.05 versus STZ group.
Figure 2
Figure 2
Effect of PIO on IL-1β level. Values represent the mean ± SEM. *P < 0.05 versus STZ group.
Figure 3
Figure 3
Effect of PIO on TNF-α level. Values represent the mean ± SEM. *P < 0.05 versus STZ group.
Figure 4
Figure 4
Islet cell death and replication represented by hematoxylin-eosin. The islet cells of diabetic rat of STZ treatment (b) showed extensive cell lysis, representing loss of plasma membrane with condensed nuclei and dissolved cytoplasm in wide intercellular spaces. In contrast, the islet cell of PIO-fed rat (c) was partly recovered. (c) Islet from a normal rat.
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