Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease: a voxel-based analysis study

Kuniaki Kiuchi; Soichiro Kitamura; Toshiaki Taoka; Fumihiko Yasuno; Masami Tanimura; Kiwamu Matsuoka; Daisuke Ikawa; Michihiro Toritsuka; Kazumichi Hashimoto; Manabu Makinodan; Jun Kosaka; Masayuki Morikawa; Kimihiko Kichikawa; Toshifumi Kishimoto

doi:10.1371/journal.pone.0104007

Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease: a voxel-based analysis study

PLoS One. 2014 Aug 5;9(8):e104007. doi: 10.1371/journal.pone.0104007. eCollection 2014.

Authors

Affiliations

¹ Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan; Sakai City Mental Health Center, Sakai, Japan.
² Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan; Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
³ Department of Radiology, Nara Medical University, Kashihara, Japan.
⁴ Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan.
⁵ Faculty of Psychology, Doshisha University, Kyoto, Japan.
⁶ Department of Psychiatry, Nara Medical University, Kashihara, Japan.
⁷ Department of Psychiatry, Nara Medical University, Kashihara, Japan; Mie Prefectural Mental Care Center, Tsu, Japan.

Abstract

Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease / complications
Alzheimer Disease / pathology*
Amnesia / complications
Amnesia / pathology*
Anisotropy
Atrophy
Cognitive Dysfunction / complications
Cognitive Dysfunction / pathology*
Demography
Female
Gray Matter / pathology*
Humans
Magnetic Resonance Imaging*
Male
White Matter / pathology*

Grants and funding

This work was financially supported by JSPS KAKENHI Grant Number 22791138. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.