Limited proteolysis: DisRUPting proteasomal inhibition

Curr Biol. 2014 Aug 4;24(15):R693-5. doi: 10.1016/j.cub.2014.06.056.


The 26S proteasome is a protease complex that completely degrades substrate proteins marked with a chain of ubiquitins, but is also able to perform endoproteolytic cleavage. A new study now demonstrates that regulated ubiquitin-proteasome-dependent processing ameliorates proteasomal inhibition.

Publication types

  • Comment

MeSH terms

  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Nuclear Respiratory Factor 1 / metabolism*
  • Proteasome Endopeptidase Complex / metabolism*
  • Proteasome Inhibitors / pharmacology*


  • Nuclear Respiratory Factor 1
  • Proteasome Inhibitors
  • Proteasome Endopeptidase Complex