Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 32 (8), 773-85

3D Bioprinting of Tissues and Organs

Affiliations

3D Bioprinting of Tissues and Organs

Sean V Murphy et al. Nat Biotechnol.

Abstract

Additive manufacturing, otherwise known as three-dimensional (3D) printing, is driving major innovations in many areas, such as engineering, manufacturing, art, education and medicine. Recent advances have enabled 3D printing of biocompatible materials, cells and supporting components into complex 3D functional living tissues. 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation. Compared with non-biological printing, 3D bioprinting involves additional complexities, such as the choice of materials, cell types, growth and differentiation factors, and technical challenges related to the sensitivities of living cells and the construction of tissues. Addressing these complexities requires the integration of technologies from the fields of engineering, biomaterials science, cell biology, physics and medicine. 3D bioprinting has already been used for the generation and transplantation of several tissues, including multilayered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures. Other applications include developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.

Similar articles

See all similar articles

Cited by 592 PubMed Central articles

See all "Cited by" articles

References

    1. Neuroimaging Clin N Am. 1994 Feb;4(1):1-8 - PubMed
    1. Science. 2005 Nov 18;310(5751):1139-43 - PubMed
    1. Nat Chem. 2012 Apr 15;4(5):349-54 - PubMed
    1. Biomaterials. 2007 Oct;28(29):4251-6 - PubMed
    1. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jun;85(6 Pt 1):061604 - PubMed

LinkOut - more resources

Feedback