Complete genome sequence of the gram-negative probiotic Escherichia coli strain Nissle 1917

J Biotechnol. 2014 Oct 10;187:106-7. doi: 10.1016/j.jbiotec.2014.07.442. Epub 2014 Aug 2.


Escherichia coli strain Nissle 1917 (EcN) is the active principle of a probiotic preparation (trade name Mutaflor(®)) used for the treatment of patients with intestinal diseases such as ulcerative colitis and diarrhea. It has GRAS (generally recognized as save) status and has been shown to be a therapeutically effective drug (Sonnenborn and Schulze, 2009). The complete genomic DNA sequence will help in identifying genes and their products which are essential for the strains probiotic nature. Genbank/EMBL/DDBJ accession number: CP007799 (chromosome).

Keywords: Escherichia coli Nissle 1917; Genome DNA sequence; Probiotic drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Escherichia coli / genetics*
  • Genome, Bacterial / genetics*
  • Molecular Sequence Data
  • Probiotics*
  • Sequence Analysis, DNA


  • DNA, Bacterial

Associated data

  • GENBANK/CP007799