Aging of the hematopoietic stem cells niche

Int J Hematol. 2014 Oct;100(4):317-25. doi: 10.1007/s12185-014-1641-8. Epub 2014 Aug 6.


Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Bone Marrow / metabolism*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Mice
  • Mice, Knockout
  • Stem Cell Niche*