DLK1-DIO3 Imprinted Cluster in Induced Pluripotency: Landscape in the Mist

Cell Mol Life Sci. 2014 Nov;71(22):4421-30. doi: 10.1007/s00018-014-1698-9. Epub 2014 Aug 7.


DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.

Publication types

  • Review

MeSH terms

  • Calcium-Binding Proteins
  • Carcinogenesis
  • Epigenesis, Genetic
  • Genomic Imprinting
  • Humans
  • Induced Pluripotent Stem Cells / enzymology
  • Induced Pluripotent Stem Cells / metabolism
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Iodide Peroxidase / genetics
  • Iodide Peroxidase / metabolism*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • MicroRNAs / metabolism
  • Transcription Factors / metabolism


  • Calcium-Binding Proteins
  • DLK1 protein, human
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • MicroRNAs
  • Transcription Factors
  • Iodide Peroxidase