An efficient method for the synthesis of quinoxaline N-oxides proceeds by the dehydrogenative N-incorporation of simple imines by C(sp(2))-H and C(sp(3))-H bond functionalization. The overall transformation involves the cleavage of three C-H bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily available tert-butyl nitrite (TBN) was employed as the NO source.
Keywords: CN bond formation; cyclization; dehydrogenative coupling; imines; nitrogen oxides.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.