Effect of deprenyl on the progression of disability in early Parkinson's disease

N Engl J Med. 1989 Nov 16;321(20):1364-71. doi: 10.1056/NEJM198911163212004.


In a clinical trial that is still in progress, we studied the ability of deprenyl and tocopherol, antioxidative agents that act through complementary mechanisms, to delay the onset of disability necessitating levodopa therapy (the primary end point) in patients with early, untreated Parkinson's disease. Eight hundred subjects were randomly assigned in a two-by-two factorial design to receive deprenyl, tocopherol, a combination of both drugs, or placebo, and were followed up to determine the frequency of development of the end point. The interim results of independent monitoring prompted a preliminary comparison of the 401 subjects assigned to tocopherol or placebo with the 399 subjects assigned to deprenyl, alone or with tocopherol. Only 97 subjects who received deprenyl reached the end point during an average 12 months of follow-up, as compared with 176 subjects who did not receive deprenyl (P less than 10(-8). The risk of reaching the end point was reduced by 57 percent for the subjects who received deprenyl (Cox hazard ratio, 0.43; 95 percent confidence limits, 0.33 and 0.55; P less than 10(-10]. The subjects who received deprenyl also had a significant reduction in their risk of having to give up full-time employment (P = 0.01). We conclude from these preliminary results that the use of deprenyl (10 mg per day) delays the onset of disability associated with early, otherwise untreated cases of Parkinson's disease.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activities of Daily Living
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Employment
  • Female
  • Follow-Up Studies
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology
  • Phenethylamines / therapeutic use*
  • Random Allocation
  • Selegiline / administration & dosage
  • Selegiline / therapeutic use*
  • Vitamin E / administration & dosage
  • Vitamin E / therapeutic use


  • Phenethylamines
  • Vitamin E
  • Selegiline
  • Levodopa