Polo-like kinase 4 shapes up

Structure. 2014 Aug 5;22(8):1071-1073. doi: 10.1016/j.str.2014.07.004.


Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole targeting of the kinase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins / chemistry*
  • Caenorhabditis elegans Proteins / metabolism*
  • Centrioles / physiology*
  • Models, Molecular*
  • Protein Kinases / chemistry*
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*


  • Caenorhabditis elegans Proteins
  • Protein Kinases
  • zyg-1 protein, C elegans
  • Protein-Serine-Threonine Kinases