Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation

Cell Metab. 2014 Aug 5;20(2):208-13. doi: 10.1016/j.cmet.2014.07.014.


The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Acetylglucosamine / metabolism*
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / pathology
  • Epigenomics
  • Glycosylation
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Signal Transduction
  • Transcription, Genetic


  • AMP-Activated Protein Kinases
  • Acetylglucosamine