A new activity for SAMHD1 in HIV restriction

Nat Med. 2014 Aug;20(8):808-9. doi: 10.1038/nm.3657.


Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.

Publication types

  • Comment

MeSH terms

  • HIV Infections / virology*
  • HIV-1 / physiology*
  • Humans
  • Monomeric GTP-Binding Proteins / genetics*
  • Monomeric GTP-Binding Proteins / metabolism*
  • RNA, Viral / metabolism*
  • SAM Domain and HD Domain-Containing Protein 1
  • Virus Replication*


  • RNA, Viral
  • SAM Domain and HD Domain-Containing Protein 1
  • SAMHD1 protein, human
  • Monomeric GTP-Binding Proteins