Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8 + tumor-infiltrating lymphocytes in ovarian cancer

Oncoimmunology. 2014 Jan 10;3:e27668. doi: 10.4161/onci.27668. eCollection 2014.


Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correlating with increased disease-specific survival.

Keywords: CD103; cancer; epithelium; tumor-infiltrating lymphocytes.