Prevention of peritendinous adhesions using an electrospun DegraPol polymer tube: a histological, ultrasonographic, and biomechanical study in rabbits

Biomed Res Int. 2014;2014:656240. doi: 10.1155/2014/656240. Epub 2014 Jul 2.


Purpose: One of the great challenges in surgical tendon rupture repair is to minimize peritendinous adhesions. In order to reduce adhesion formation, a physical barrier was applied to a sutured rabbit Achilles tendon, with two different immobilization protocols used postoperatively.

Methods: Thirty New Zealand white rabbits received a laceration on the Achilles tendon, sutured with a 4-strand Becker suture, and half of the rabbits got a DegraPol tube at the repair site. While fifteen rabbits had their treated hind leg in a 180° stretched position during 6 weeks (adhesion provoking immobilization), the other fifteen rabbits were recasted with a 150° position after 3 weeks (adhesion inhibiting immobilization). Adhesion extent was analysed macroscopically, via ultrasound and histology. Inflammation was determined histologically. Biomechanical properties were analysed.

Results: Application of a DegraPol tube reduced adhesion formation by approximately 20%--independently of the immobilization protocol. Biomechanical properties of extracted specimen were not affected by the tube application. There was no serious inflammatory reaction towards the implant material.

Conclusions: Implantation of a DegraPol tube tightly set around a sutured tendon acts as a beneficial physical barrier and prevents adhesion formation significantly--without affecting the tendon healing process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Achilles Tendon / diagnostic imaging
  • Achilles Tendon / pathology
  • Achilles Tendon / surgery*
  • Animals
  • Humans
  • Orthopedic Procedures
  • Polyesters / therapeutic use*
  • Polymers / therapeutic use
  • Polyurethanes / therapeutic use*
  • Rabbits
  • Rupture / diagnostic imaging
  • Rupture / pathology
  • Rupture / surgery
  • Tendon Injuries / diagnostic imaging
  • Tendon Injuries / pathology
  • Tendon Injuries / surgery*
  • Tissue Adhesions / diagnostic imaging
  • Tissue Adhesions / physiopathology*
  • Ultrasonography
  • Wound Healing


  • DegraPol
  • Polyesters
  • Polymers
  • Polyurethanes