Development of a new technique for the efficient delivery of aerosolized medications to infants on mechanical ventilation

Pharm Res. 2015 Jan;32(1):321-36. doi: 10.1007/s11095-014-1466-4. Epub 2014 Aug 8.


Purpose: To evaluate the efficiency of a new technique for delivering aerosols to intubated infants that employs a new Y-connector, access port administration of a dry powder, and excipient enhanced growth (EEG) formulation particles that change size in the airways.

Methods: A previously developed CFD model combined with algebraic correlations were used to predict delivery system and lung deposition of typical nebulized droplets (MMAD = 4.9 μm) and EEG dry powder aerosols. The delivery system consisted of a Y-connector [commercial (CM); streamlined (SL); or streamlined with access port (SL-port)] attached to a 4-mm diameter endotracheal tube leading to the airways of a 6-month-old infant.

Results: Compared to the CM device and nebulized aerosol, the EEG approach with an initial 0.9 μm aerosol combined with the SL and SL-port geometries reduced device depositional losses by factors of 3-fold and >10-fold, respectively. With EEG powder aerosols, the SL geometry provided the maximum tracheobronchial deposition fraction (55.7%), whereas the SL-port geometry provided the maximum alveolar (67.6%) and total lung (95.7%) deposition fractions, respectively.

Conclusions: Provided the aerosol can be administered in the first portion of the inspiration cycle, the proposed new method can significantly improve the deposition of pharmaceutical aerosols in the lungs of intubated infants.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aerosols / administration & dosage*
  • Aerosols / chemistry
  • Aerosols / pharmacokinetics
  • Drug Delivery Systems* / instrumentation
  • Drug Delivery Systems* / methods
  • Equipment Design*
  • Excipients / chemistry
  • Humans
  • Infant
  • Inhalation / physiology
  • Intubation, Intratracheal
  • Lung / metabolism
  • Male
  • Particle Size
  • Respiration, Artificial*
  • Tissue Distribution


  • Aerosols
  • Excipients