Abstract
In this issue of Blood, Deng et al have clarified the molecular mechanism critical for the angiopoietin-like 2 (Angptl2) binding to its receptor leukocyte immunoglobulin-like receptor B2 (LILRB2), providing a theoretical basis for Angptl2-driven ex vivo expansion of human hematopoietic stem cells (HSCs).
MeSH terms
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Angiopoietin-Like Protein 2
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Angiopoietin-like Proteins
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Angiopoietins / chemistry*
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Angiopoietins / metabolism*
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Animals
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Hematopoietic Stem Cells / metabolism*
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Humans
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Membrane Glycoproteins / chemistry*
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Membrane Glycoproteins / metabolism*
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Receptors, Immunologic / chemistry*
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Receptors, Immunologic / metabolism*
Substances
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ANGPTL2 protein, human
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Angiopoietin-Like Protein 2
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Angiopoietin-like Proteins
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Angiopoietins
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LILRB2 protein, human
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Membrane Glycoproteins
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Receptors, Immunologic