Unveiling Angptl2, a rising HSC expander

Blood. 2014 Aug 7;124(6):833-4. doi: 10.1182/blood-2014-06-581629.

Abstract

In this issue of Blood, Deng et al have clarified the molecular mechanism critical for the angiopoietin-like 2 (Angptl2) binding to its receptor leukocyte immunoglobulin-like receptor B2 (LILRB2), providing a theoretical basis for Angptl2-driven ex vivo expansion of human hematopoietic stem cells (HSCs).

Publication types

  • Comment

MeSH terms

  • Angiopoietin-like Proteins
  • Angiopoietins / chemistry*
  • Angiopoietins / metabolism*
  • Animals
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Membrane Glycoproteins / chemistry*
  • Membrane Glycoproteins / metabolism*
  • Receptors, Immunologic / chemistry*
  • Receptors, Immunologic / metabolism*

Substances

  • ANGPTL2 protein, human
  • Angiopoietin-like Proteins
  • Angiopoietins
  • LILRB2 protein, human
  • Membrane Glycoproteins
  • Receptors, Immunologic