Leptin receptor makes its mark on MSCs

Yumi Matsuzaki; Yo Mabuchi; Hideyuki Okano

doi:10.1016/j.stem.2014.07.001

Leptin receptor makes its mark on MSCs

Cell Stem Cell. 2014 Aug 7;15(2):112-4. doi: 10.1016/j.stem.2014.07.001.

Authors

Yumi Matsuzaki¹, Yo Mabuchi², Hideyuki Okano³

Affiliations

¹ Department of Life Science Laboratory of Tumor Biology, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan.
² Department of Biochemistry and Biophysics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
³ Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: hidokano@a2.keio.jp.

PMID: 25105573
DOI: 10.1016/j.stem.2014.07.001

Abstract

Although mesenchymal stem/stromal cells (MSCs) are an important component of the hematopoietic niche, the markers that correlate with their physiological functions have not been defined. In this issue of Cell Stem Cell, Zhou et al. (2014) identify the Leptin Receptor as a marker for prospective identification and in vivo fate mapping of bone marrow MSCs.

Publication types

Comment

MeSH terms

Animals
Bone and Bones / metabolism*
Male
Mesenchymal Stem Cells / cytology*
Receptors, Leptin / metabolism*

Substances

Receptors, Leptin
leptin receptor, mouse