Optimizing dosing of oncology drugs

Clin Pharmacol Ther. 2014 Nov;96(5):572-9. doi: 10.1038/clpt.2014.153. Epub 2014 Aug 8.


The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during the development and premarketing evaluation of investigational new drugs.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Dose-Response Relationship, Drug
  • Humans
  • Medication Adherence
  • Time Factors


  • Antineoplastic Agents