Baicalin attenuates alzheimer-like pathological changes and memory deficits induced by amyloid β1-42 protein

Metab Brain Dis. 2015 Apr;30(2):537-44. doi: 10.1007/s11011-014-9601-9. Epub 2014 Aug 10.


Baicalin is one bioactive flavone with anti-inflammatory and neuroprotective activities. The neuroprotective effects of baicalin on pathological changes and behavioral deficits were explored in a mouse model of amyloid β (Aβ)(1-42) protein-induced Alzheimer's disease (AD). Mice received a bilateral injection of Aβ(1-42) protein into the hippocampus, then they were treated with baicalin (30, 50 and 100 mg/kg body weight, orally) or Tween 80. The therapeutic effects of baicalin were monitored by Morris water maze trial and probe test. Then mice were sacrificed for immunohistochemistry and western blot analysis. After a relatively short-term treatment of 14 days, 100 mg/kg of baicalin significantly ameliorated memory impairment in the Morris water maze test and probe test, and also attenuated glial cell activations and increase of TNF-α and IL-6 expressions induced by Aβ(1-42) protein. These results suggest that baicalin ameliorated Aβ(1-42) protein-related pathology and cognitive dysfunction via its anti-neuroinflammatory activity, and may be a potential candidate for the treatment of AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / chemically induced
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / psychology*
  • Amyloid beta-Peptides / toxicity*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Cognition Disorders / drug therapy
  • Cognition Disorders / psychology
  • Cytokines / metabolism
  • Flavonoids / therapeutic use*
  • Immunohistochemistry
  • Macrophage Activation / drug effects
  • Male
  • Maze Learning / drug effects
  • Memory Disorders / chemically induced
  • Memory Disorders / drug therapy*
  • Memory Disorders / etiology*
  • Mice
  • Mice, Inbred ICR
  • Neuroglia / drug effects
  • Peptide Fragments / toxicity*


  • Amyloid beta-Peptides
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • Flavonoids
  • Peptide Fragments
  • amyloid beta-protein (1-42)
  • baicalin