Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers

Clin Immunol. 2014 Nov;155(1):17-26. doi: 10.1016/j.clim.2014.07.010. Epub 2014 Aug 7.

Abstract

TNF-related apoptosis ligand (TRAIL) induces apoptosis of HIV-1-exposed CD4 T cells expressing the death receptor 5 (DR5) in vitro and has been associated with reduced CD4 T cell number in viremic HIV-1-infected patients. Alterations of the TRAIL/DR5 apoptotic pathway could be involved in the absence of massive CD4 T cell depletion in HIV-1-infected controllers (HIC). We studied here apoptosis of CD4 T cells from HIV-infected progressors and controllers. Reduced apoptosis of CD4 T cells from HIC was observed upon HIV stimulation. This lower apoptosis correlated with a deficiency of DR5 cell surface expression by CD4 T cells upon HIV-1 stimulation. The significant lower apoptosis observed in CD4 T cells after HIV exposure, associated with lower expression of membrane DR5 could explain the better survival of HIV-specific CD4 T cells from HIV controllers. The levels of DR5 cell surface expression on CD4 T cells could represent a new prognostic marker.

Keywords: Apoptosis; CD4+ T cell; DR5; HIV infected controllers; TRAIL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apoptosis / physiology*
  • CD4-Positive T-Lymphocytes / physiology*
  • Cell Membrane
  • Gene Expression Regulation / immunology*
  • HIV / physiology
  • HIV Infections / immunology
  • HIV Infections / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Receptors, TNF-Related Apoptosis-Inducing Ligand / genetics
  • Receptors, TNF-Related Apoptosis-Inducing Ligand / metabolism*
  • Viremia

Substances

  • Receptors, TNF-Related Apoptosis-Inducing Ligand