Immunology of inflammatory bowel disease and molecular targets for biologics

Gastroenterol Clin North Am. 2014 Sep;43(3):405-24. doi: 10.1016/j.gtc.2014.05.003.


Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in high-throughput technologies provide an opportunity to monitor the dynamic and complex immune system, which may to lead to a more personalized treatment approach in IBD.

Keywords: Adaptive immunity; Biologics; IBD; Immunology; Innate immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dendritic Cells / immunology
  • Humans
  • Immunity, Innate*
  • Immunity, Mucosal*
  • Inflammatory Bowel Diseases / drug therapy*
  • Inflammatory Bowel Diseases / immunology*
  • Intestines / microbiology*
  • Macrophages / immunology
  • Microbiota
  • T-Lymphocytes / immunology*