Results of catheter ablation of atrial fibrillation in hypertrophied hearts - Comparison between primary and secondary hypertrophy

J Cardiol. 2015 Jun;65(6):474-8. doi: 10.1016/j.jjcc.2014.07.005. Epub 2014 Aug 10.


Background and purpose: Approximately 20-25% of the patients with hypertrophic cardiomyopathy (HCM) develop atrial fibrillation (AF) during the clinical course of the disease, a percentage significantly larger than that of the general population. The purpose of the present study was to report on the procedural results of patients with AF and either primary or secondary left ventricular hypertrophy (LVH).

Methods and subjects: Twenty-two consecutive HCM patients (55% male, mean age 57±8 years) with symptomatic AF, having undergone AF ablation procedures between September 2009 and July 2012 were compared with respect to procedural outcome and follow-up characteristics with 22 matched controls with secondary cardiac hypertrophy (64% male, 63±10 years) from our prospective AF catheter ablation registry.

Results and conclusion: Radiofrequency catheter ablation (RFCA) was successful in restoring long-term sinus rhythm in patients with LVH due to HCM and due to secondary etiology. However, patients with HCM needed more RFCA procedures and frequently additional antiarrhythmic drug therapy in order to maintain sinus rhythm.

Keywords: Atrial fibrillation; Hypertrophic cardiomyopathy; Left ventricular hypertrophy; Radiofrequency catheter ablation.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Anti-Arrhythmia Agents / therapeutic use
  • Atrial Fibrillation / drug therapy
  • Atrial Fibrillation / etiology
  • Atrial Fibrillation / surgery*
  • Cardiomyopathy, Hypertrophic / complications
  • Case-Control Studies
  • Catheter Ablation / methods*
  • Female
  • Humans
  • Hypertrophy, Left Ventricular / complications*
  • Male
  • Middle Aged
  • Prospective Studies
  • Treatment Outcome


  • Anti-Arrhythmia Agents