Response to rituximab in a case of lupus associated digital ischemia

Case Rep Rheumatol. 2014:2014:763608. doi: 10.1155/2014/763608. Epub 2014 Jul 9.


We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator agents, a serious progression to digital gangrene over a one-month period was observed. Surprisingly, her nonhealing digital lesions improved after two cycles of rituximab (RTX) administration.