STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

Nina Le Bert; Adeline R Lam; Samantha Sw Ho; Yu J Shen; Mo M Liu; Stephan Gasser

doi:10.4161/onci.29259

STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

Oncoimmunology. 2014 Jun 25:3:e29259. doi: 10.4161/onci.29259. eCollection 2014.

Authors

Nina Le Bert¹, Adeline R Lam², Samantha Sw Ho¹, Yu J Shen², Mo M Liu¹, Stephan Gasser²

Affiliations

¹ Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.
² Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore ; NUS Graduate School for Integrative Sciences and Engineering; National University of Singapore; Singapore.

Abstract

The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).^1,2 We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of RAE-1 ligands for NKG2D.^3.

Keywords: DNA sensor; NKG2D; Natural killer cells; signal transduction; tumor immunology.