In vitro dynamic degradation behavior of new magnesium alloy for orthopedic applications

J Biomed Mater Res B Appl Biomater. 2015 May;103(4):807-15. doi: 10.1002/jbm.b.33259. Epub 2014 Aug 13.

Abstract

We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.

Keywords: SEM; biodegradation; magnesium; mechanical properties; zinc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys / chemistry*
  • Compressive Strength
  • Humans
  • Magnesium / chemistry*
  • Materials Testing*
  • Orthopedic Procedures
  • Weight-Bearing

Substances

  • Alloys
  • Magnesium