Sex is a stronger predictor of colorectal adenoma and advanced adenoma than fecal occult blood test

Med Oncol. 2014 Sep;31(9):151. doi: 10.1007/s12032-014-0151-0. Epub 2014 Aug 14.


Due to high costs and limited availability of screening colonoscopy, some screening programs require a positive fecal occult blood test (FOBT) before screening colonoscopy is remunerated. As male sex is a strong predictor of adenoma and advanced adenoma, we evaluated whether a positive FOBT or male sex is a stronger risk factor for adenoma and advanced adenoma. FOBT and screening colonoscopy results from 18.665 consecutive patients participating in a "national health check program" between 2009 and 2011 were included in this cohort study. Age-corrected adenoma detection rates (ADR), advanced adenoma detection rates (AADR) and carcinoma detection rates were calculated for men and women according to FOBT result separately. ADR and AADR in FOBT-positive men (34.6 and 11.8 %) and FOBT-negative men (29.1 and 7.6 %) were higher than ADR and AADR in FOBT-positive women (20 and 6.9 %) and in FOBT-negative women (17.6 and 4.4 %), (p = 0.0003). Men with negative FOBT were at higher risk of having an adenoma and advanced adenoma than women with positive FOBT (p < 0.0001). Odds ratios of a positive FOBT for ADR and AADR were 1.3 (1.1-1.5) (p = 0.0047) and 1.6 (1.2-2.1) (p < 0.0001), respectively. Odds ratios of male sex to predict ADR and AADR were significantly higher with 1.9 (1.8-2.1) and 1.8 (1.6-2), respectively (p < 0.001). Male sex is a stronger predictor for colorectal adenoma and advanced adenoma than positive FOBT. These results should be taken into account analyzing FOBT-based screening programs.

MeSH terms

  • Adenoma / diagnosis*
  • Adenoma / epidemiology*
  • Adenoma / physiopathology
  • Aged
  • Aged, 80 and over
  • Austria / epidemiology
  • Colonic Polyps
  • Colonoscopy
  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / epidemiology*
  • Colorectal Neoplasms / physiopathology
  • Early Detection of Cancer
  • Female
  • Humans
  • Male
  • Mass Screening
  • Middle Aged
  • Occult Blood*
  • Odds Ratio
  • Sex Factors