Isotretinoin and night blindness

Australas J Dermatol. 2014 Aug;55(3):222-4. doi: 10.1111/ajd.12107. Epub 2013 Oct 8.


Isotretinoin is an effective and increasingly popular treatment for acne vulgaris. There have been reports of night blindness as a side-effect of treatment although the evidence does not demonstrate a clear causal relationship between isotretinoin therapy and the risk of night blindness. Nevertheless, considering the lack of evidence in this area, it is important to educate patients about this potential consequence, which may become longstanding and even irreversible, and encourage them to promptly report changes in their night vision.

Keywords: acne; isotretinoin; night blindness; night vision; synthetic retinoids.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris / drug therapy
  • Animals
  • Dermatologic Agents / adverse effects*
  • Humans
  • Isotretinoin / adverse effects*
  • Night Blindness / chemically induced*


  • Dermatologic Agents
  • Isotretinoin