Regulation of microRNA function in somatic stem cell proliferation and differentiation

Nat Rev Mol Cell Biol. 2014 Sep;15(9):565-76. doi: 10.1038/nrm3854. Epub 2014 Aug 13.


microRNAs (miRNAs) are important modulators of development. Owing to their ability to simultaneously silence hundreds of target genes, they have key roles in large-scale transcriptomic changes that occur during cell fate transitions. In somatic stem and progenitor cells--such as those involved in myogenesis, haematopoiesis, skin and neural development--miRNA function is carefully regulated to promote and stabilize cell fate choice. miRNAs are integrated within networks that form both positive and negative feedback loops. Their function is regulated at multiple levels, including transcription, biogenesis, stability, availability and/or number of target sites, as well as their cooperation with other miRNAs and RNA-binding proteins. Together, these regulatory mechanisms result in a refined molecular response that enables proper cellular differentiation and function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Proliferation*
  • Humans
  • MicroRNAs / metabolism*
  • Stem Cells / cytology
  • Stem Cells / metabolism*


  • MicroRNAs