Aggressive natural killer-cell leukemia: classical presentation of a rare disease

Indian J Pathol Microbiol. Jul-Sep 2014;57(3):483-5. doi: 10.4103/0377-4929.138787.


Aggressive natural killer-cell leukaemia is a rare aggressive form of natural killer-cell neoplasm. We report a case of a 40-year-old male who presented with jaundice, raised blood counts,generalised lymphadenopathy and hepatosplenomegaly. The diagnosis was established by flow cytometric analysis of bone marrow aspirate. The patient, however, succumbed to his illness within 2 weeks of starting chemotherapy. To the best of our knowledge, this is the third reported case from India.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Bone Marrow / pathology
  • Fatal Outcome
  • Flow Cytometry
  • Humans
  • India
  • Killer Cells, Natural*
  • Leukemia / diagnosis*
  • Leukemia / drug therapy
  • Leukemia / pathology*
  • Lymphocytosis
  • Male
  • Microscopy
  • Rare Diseases / diagnosis
  • Rare Diseases / drug therapy
  • Rare Diseases / pathology


  • Antineoplastic Agents