Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

Scott J Bultman; Christian Jobin

doi:10.1016/j.chom.2014.07.011

Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

Cell Host Microbe. 2014 Aug 13;16(2):143-145. doi: 10.1016/j.chom.2014.07.011.

Authors

Scott J Bultman¹, Christian Jobin²

Affiliations

¹ Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27516, USA. Electronic address: scott_bultman@med.unc.edu.
² Department of Infectious Diseases & Pathology, Department of Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address: christian.jobin@medicine.ufl.edu.

Abstract

Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cells, suggesting that it can act as an oncometabolite.

Publication types

Comment

MeSH terms

Animals
Colorectal Neoplasms / metabolism*
Colorectal Neoplasms / pathology*
Dietary Carbohydrates / metabolism*
MutS Homolog 2 Protein / metabolism*

Substances

Dietary Carbohydrates
MutS Homolog 2 Protein

Abstract

Publication types

MeSH terms

Substances

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