[Effect of extracts of Geranium ayavacense W. (Pasuchaca) on glycemia on rats with experimental diabetes mellitus]

Rev Peru Med Exp Salud Publica. 2014 Apr;31(2):261-6.
[Article in Spanish]


Objectives: To determine if the lyophilized aqueous extract of Geranium ayavacense (Pasuchaca) has any effect on glycemia in rats with experimental diabetes mellitus.

Materials and methods: Experimental diabetes was induced with alloxan. Rats included in the study met the following criteria: glycemia greater than 200 mg/dL post administration of alloxan, and with a weight greater than 200 g. Rats with experimental diabetes were divided into six groups of eight rats each. Group I received 3 mL of distilled water (control); group II received Geranium ayavacense 12.7 mg/kg; group III received Geranium ayavacense 100 mg/kg; group IV received Geranium ayavacense 200 mg/kg; group V received Geranium ayavacense 300 mg/kg; group VI received Geranium ayavacense 500 mg/kg. Basal glycemia was determined. Glycemia evaluations were performed at the 1st, 3rd, 6th, 12th and 24th hour after administrating the different interventions.

Results: Geranium ayavacense groups of 300 and 500 mg/kg decreased glycemia significantly (p <0.01) in every hour assessed after administration of the extract, when compared with the control group. Geranium ayavacense group of 300 mg/kg decreased their blood glucose 8.14; 10.68; 14.87; 19.36 and 23.7% in the 1st, 3rd, 6th, 12th and 24th hour respectively.

Conclusions: Under experimental conditions, the aqueous extract of Geranium ayavacense has hypoglycemic effects in rats.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis*
  • Blood Glucose / drug effects*
  • Diabetes Mellitus, Experimental / blood*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Geranium*
  • Male
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Rats


  • Blood Glucose
  • Plant Extracts