Cumulative dietary exposure to a selected group of pesticides of the triazole group in different European countries according to the EFSA guidance on probabilistic modelling

Food Chem Toxicol. 2015 May;79:13-31. doi: 10.1016/j.fct.2014.08.004. Epub 2014 Aug 12.


The practicality was examined of performing a cumulative dietary exposure assessment according to the requirements of the EFSA guidance on probabilistic modelling. For this the acute and chronic cumulative exposure to triazole pesticides was estimated using national food consumption and monitoring data of eight European countries. Both the acute and chronic cumulative dietary exposures were calculated according to two model runs (optimistic and pessimistic) as recommended in the EFSA guidance. The exposures obtained with these model runs differed substantially for all countries, with the highest exposures obtained with the pessimistic model run. In this model run, animal commodities including cattle milk and different meat types, entered in the exposure calculations at the level of the maximum residue limit (MRL), contributed most to the exposure. We conclude that application of the optimistic model run on a routine basis for cumulative assessments is feasible. The pessimistic model run is laborious and the exposure results could be too far from reality. More experience with this approach is needed to stimulate the discussion of the feasibility of all the requirements, especially the inclusion of MRLs of animal commodities which seem to result in unrealistic conclusions regarding their contribution to the dietary exposure.

Keywords: Acute exposure; Chronic exposure; Cumulative Assessment Group; Cumulative dietary exposure; EFSA; Probabilistic modelling.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Cattle
  • Child
  • Diet / adverse effects*
  • Diet Surveys
  • Ecotoxicology / methods*
  • European Union
  • Feasibility Studies
  • Female
  • Food Contamination*
  • Guidelines as Topic
  • Humans
  • Male
  • Meat / adverse effects
  • Meat / analysis
  • Middle Aged
  • Milk / adverse effects
  • Milk / chemistry
  • Models, Statistical*
  • Pesticide Residues / analysis
  • Pesticide Residues / toxicity*
  • Pesticides / analysis
  • Pesticides / toxicity*
  • Risk Assessment / standards
  • Triazoles / analysis
  • Triazoles / toxicity*
  • Young Adult


  • Pesticide Residues
  • Pesticides
  • Triazoles