Treatment of FANCA cells with resveratrol and N-acetylcysteine: a comparative study

PLoS One. 2014 Aug 15;9(7):e104857. doi: 10.1371/journal.pone.0104857. eCollection 2014.


Fanconi anemia (FA) is a genetic disorder characterised by chromosome instability, cytokine ipersensibility, bone marrow failure and abnormal haematopoiesis associated with acute myelogenous leukemia. Recent reports are contributing to characterize the peculiar FA metabolism. Central to these considerations appears that cells from complementation group A (FANCA) display an altered red-ox metabolism. Consequently the possibility to improve FA phenotypical conditions with antioxidants is considered. We have characterized from the structural and biochemical point of view the response of FANCA lymphocytes to N-acetyl-cysteine (NAC) and resveratrol (RV). Surprisingly both NAC and RV failed to revert all the characteristic of FA phenotype and moreover their effects are not super imposable. Our data suggest that we must be aware of the biological effects coming from antioxidant treatment.

Publication types

  • Comparative Study

MeSH terms

  • Acetylcysteine / pharmacology*
  • Antioxidants / pharmacology*
  • Cells, Cultured
  • Drug Evaluation, Preclinical
  • Fanconi Anemia / drug therapy*
  • Fanconi Anemia / pathology
  • Humans
  • Mitochondria / pathology
  • Reactive Oxygen Species / metabolism
  • Resveratrol
  • Stilbenes / pharmacology*


  • Antioxidants
  • Reactive Oxygen Species
  • Stilbenes
  • Resveratrol
  • Acetylcysteine