Review
doi: 10.1016/0968-0004(89)90001-7.
GTP-binding proteins as possible targets for protein kinase C action
- PMID: 2512697
- DOI: 10.1016/0968-0004(89)90001-7
Item in Clipboard
Review
GTP-binding proteins as possible targets for protein kinase C action
Trends Biochem Sci.
1989 Sep.
Abstract
The alpha-subunits of two guanine nucleotide binding proteins Gi and transducin, as well as the beta-subunit of transducin, serve as substrates for phosphorylation by the Ca2+- and phospholipid-dependent protein kinase C (PKC). Phosphorylation of the alpha-subunit of transducin is strictly dependent on its conformation and it is only the inactive form that is subjected to phosphorylation by PKC. This review will focus on the proposition that G proteins may serve as cellular targets for modulatory actions of PKC.
Comment in
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Phosphorylation of Gi in intact cells.Trends Biochem Sci. 1990 Jan;15(1):13. doi: 10.1016/0968-0004(90)90122-r. Trends Biochem Sci. 1990. PMID: 2107611 Review. No abstract available.
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