Detection of a pneumonia virus of mice (PVM) in an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS)

Vet Microbiol. 2014 Sep 17;173(1-2):136-40. doi: 10.1016/j.vetmic.2014.07.012. Epub 2014 Jul 29.

Abstract

A pneumonia virus of mice (PVM) from an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS) was detected and genetically characterized. The affected hedgehog had a nonsuppurative encephalitis with vacuolization of the white matter, and the brain samples yielded RNA reads highly homogeneous to PVM strain 15 (96.5% of full genomic sequence homology by analysis of next generation sequencing). PVM antigen was also detected in the brain and the lungs immunohistochemically. A PVM was strongly suggested as a causative agent of encephalitis of a hedgehog with suspected WHS. This is a first report of PVM infection in hedgehogs.

Keywords: African hedgehog (Atelerix arbiventris); Encephalitis; Pneumonia virus of mice (PVM).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / pathology
  • Brain / virology
  • Encephalitis, Viral / pathology
  • Encephalitis, Viral / veterinary*
  • Encephalitis, Viral / virology
  • Female
  • Hedgehogs
  • High-Throughput Nucleotide Sequencing
  • Lung / pathology
  • Lung / virology
  • Mice
  • Murine pneumonia virus / genetics
  • Murine pneumonia virus / isolation & purification*
  • Pneumovirus Infections / pathology
  • Pneumovirus Infections / veterinary*
  • Pneumovirus Infections / virology