Physical activity modifies the associations between genetic variants and blood pressure in European adolescents

J Pediatr. 2014 Nov;165(5):1046-9.e1-2. doi: 10.1016/j.jpeds.2014.07.007. Epub 2014 Aug 14.

Abstract

We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥ 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Blood Pressure / genetics*
  • Blood Pressure Determination
  • Energy Metabolism
  • European Continental Ancestry Group / genetics
  • Exercise / physiology*
  • Female
  • Humans
  • Hypertension / etiology
  • Hypertension / genetics*
  • Life Style
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Nitric Oxide Synthase Type III / genetics*
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide*

Substances

  • NOS3 protein, human
  • Nitric Oxide Synthase Type III
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)