Coexistence of Gastrointestinal Stromal Tumors (GISTs) and Pheochromocytoma in Three Cases of Neurofibromatosis Type 1 (NF1) With a Review of the Literature

Intern Med. 2014;53(16):1783-9. doi: 10.2169/internalmedicine.53.2012. Epub 2014 Aug 15.

Abstract

It is well known that neurofibromatosis type 1 (NF1) is uncommonly associated with pheochromocytoma development and also, to a larger extent, with gastrointestinal stromal tumors (GISTs). We herein document three cases with the rare condition of NF1 coexisting with GIST and pheochromocytoma, while one of them also has a composite tumor and another has papillary thyroid carcinoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Gland Neoplasms / pathology*
  • Adrenal Gland Neoplasms / surgery
  • Adult
  • Carcinoma / pathology*
  • Carcinoma / surgery
  • Carcinoma, Papillary
  • Female
  • Gastrointestinal Neoplasms / pathology*
  • Gastrointestinal Neoplasms / surgery
  • Gastrointestinal Stromal Tumors / pathology*
  • Gastrointestinal Stromal Tumors / surgery
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Multiple Primary / surgery
  • Neurofibromatosis 1 / pathology*
  • Neurofibromatosis 1 / surgery
  • Rare Diseases
  • Thyroid Cancer, Papillary
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / surgery
  • Treatment Outcome