Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice

Vaccine. 2014 Sep 22;32(42):5375-8. doi: 10.1016/j.vaccine.2014.07.087. Epub 2014 Aug 15.


A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protected with no significant weight loss. The results have direct implications on how to overcome potential vaccine shortage and identify donors for immune sera for passive immunization.

Keywords: H7N9; Influenza; Vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood
  • Cross Reactions
  • Influenza A Virus, H7N7 Subtype
  • Influenza A Virus, H7N9 Subtype*
  • Influenza Vaccines / immunology*
  • Mice, Inbred BALB C
  • Neutralization Tests
  • Orthomyxoviridae Infections / prevention & control*
  • Reassortant Viruses / immunology
  • Vaccines, Inactivated / immunology


  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, Inactivated