Abstract
We report the effects of 88 μg·kg(-1) of epinephrine (1:10,000) injected into the caudal epidural space of a 42-week postconceptual age infant. No long-term neurological or cardiovascular sequelae occurred. Noninvasive cardiac output (CO) monitoring revealed increased CO, contractility, and stroke volume for about an hour, accompanied by a reduction in peripheral vascular resistance and a modest increase in pulse and blood pressure.
Trial registration:
ClinicalTrials.gov NCT01499615.
Keywords:
adverse events; drug overdose; epinephrine; noninvasive monitors; pharmacodynamics; sacral epidural.
© 2014 John Wiley & Sons Ltd.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Agonists / administration & dosage*
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Anesthesia, Epidural / methods*
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Blood Pressure / drug effects
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Cardiac Output / drug effects
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Epinephrine / administration & dosage*
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Female
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Follow-Up Studies
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Heart Rate / drug effects
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Heart Ventricles / drug effects
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Humans
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Hypertension / chemically induced
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Infant
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Injections, Epidural
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Medication Errors*
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Monitoring, Physiologic / methods
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Tachycardia / chemically induced
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Vascular Resistance / drug effects
Substances
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Adrenergic alpha-Agonists
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Epinephrine
Associated data
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ClinicalTrials.gov/NCT01499615