Antioxidant and antiproliferative activities of twenty-four Vitis vinifera grapes

Zhenchang Liang; Lailiang Cheng; Gan-Yuan Zhong; Rui Hai Liu

doi:10.1371/journal.pone.0105146

Antioxidant and antiproliferative activities of twenty-four Vitis vinifera grapes

PLoS One. 2014 Aug 18;9(8):e105146. doi: 10.1371/journal.pone.0105146. eCollection 2014.

Authors

Zhenchang Liang¹, Lailiang Cheng², Gan-Yuan Zhong³, Rui Hai Liu⁴

Affiliations

¹ Institute of Botany, the Chinese Academy of Sciences, Beijing, China; Department of Food Science, Cornell University, Ithaca, New York, United States of America.
² Department of Horticulture, Cornell University, Ithaca, New York, United States of America.
³ USDA -ARS Grape Genetics Research Unit, Geneva, New York, United States of America.
⁴ Department of Food Science, Cornell University, Ithaca, New York, United States of America.

Abstract

Grapes are rich in phytochemicals with many proven health benefits. Phenolic profiles, antioxidant and antiproliferative activities of twenty-four selected Vitis vinifera grape cultivars were investigated in this study. Large ranges of variation were found in these cultivars for the contents of total phenolics (95.3 to 686.5 mg/100 g) and flavonoids (94.7 to 1055 mg/100 g) and antioxidant activities (oxygen radical absorbance capacity 378.7 to 3386.0 mg of Trolox equivalents/100 g and peroxylradical scavenging capacity14.2 to 557 mg of vitamin C equivalents/100 g), cellular antioxidant activities (3.9 to 139.9 µmol of quercetin equivalents/100 g without PBS wash and 1.4 to 95.8 µmol of quercetin equivalents /100 g with PBS wash) and antiproliferative activities (25 to 82% at the concentrations of 100 mg/mL extracts).The total antioxidant activities were significantly correlated with the total phenolics and flavonoids. However, no significant correlations were found between antiproliferative activities and total phenolics or total flavonoids content. Wine grapes and color grapes showed much higher levels of phytochemicals and antioxidant activities than table grapes and green/yellow grapes. Several germplasm accessions with much high contents of phenolics and flavonoids, and total antioxidant activity were identified. These germplasm can be valuable sources of genes for breeding grape cultivars with better nutritional qualities of wine and table grapes in the future.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antioxidants / analysis*
Flavonoids / analysis
Phenols / analysis
Vitis / chemistry*

Substances

Antioxidants
Flavonoids
Phenols

Grants and funding

The authors are grateful to Mr. Bernard Prins of the USDA-ARS National Clonal Germplasm Repository for Fruit and Nut Crops in Davis, California and Dr. Christopher Owens of the USDA-ARS Grape Genetics Research Unit in Geneva, New York for providing V. vinifera berry samples. This work was supported by a Special Cooperative Agreement between USDA-ARS and Cornell University. USDA-ARS is an equal opportunity provider and employer. This project was supported by the United States Department of Agriculture-Agricultural Research Service Project 1910-21220-004-00D through a Specific Cooperative Agreement with Cornell University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.