Abstract
Present methods to synthesize 1,3-dithiane molecules require either harsh reaction conditions or highly specialized reagents. We have developed a catalytic dithioacetalization process that directly gains access to the corresponding 1,3-dithianes using aldehydes and 2-chloro-1,3-dithiane in a highly efficient manner. This methodology is beneficial due to mildness of the reaction conditions, and the dithioacetaliation process results in good to excellent yields by using 15 mol % of an iron catalyst.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Catalysis
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Chlorides / chemistry*
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Ferric Compounds / chemistry*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds, 1-Ring / chemistry*
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Indicators and Reagents
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Molecular Structure
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Quinolizines
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Stereoisomerism
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Sulfur Compounds
Substances
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2-chloro-1,3-dithiane
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Aldehydes
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Chlorides
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Ferric Compounds
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Heterocyclic Compounds
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Heterocyclic Compounds, 1-Ring
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Indicators and Reagents
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Quinolizines
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Sulfur Compounds
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dithiane
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1,3-dithiane
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ferric chloride