Melatonin improve the sperm quality in forced swimming test induced oxidative stress in nandrolone treated Wistar rats

Acta Med Iran. 2014;52(7):496-504.


This study investigates the effects of melatonin on the sperm quality and testis weight after the combination of swimming exercise and nandrolone decanoate (DECA). Two groups of male Wistar rats were treated for eight weeks as follows; group A consist of CO (control), Sham, N (DECA), S (swimming) and NS (DECA plus swimming); and group B: Sham M (sham melatonin), M (melatonin), MN (melatonin plus DECA), MS (melatonin plus swimming), MNS (melatonin, DECA plus swimming). The motility of sperm was significantly improved in melatonin groups in comparison to N, S and NS groups (P≤0.05). The left testes weight was decreased in N, NS and MNS groups, and the right testes weight was decreased in N,S,NS, MS and MNS groups in compare with the control group. This study concluded that melatonin probably could improve the sperm motility and sex organs weight after the combination of DECA and exercise.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anabolic Agents / pharmacology
  • Animals
  • Antioxidants / pharmacology
  • Disease Models, Animal
  • Humans
  • Male
  • Melatonin / pharmacology*
  • Nandrolone / analogs & derivatives*
  • Nandrolone / pharmacology
  • Nandrolone Decanoate
  • Oxidative Stress / drug effects*
  • Physical Conditioning, Animal
  • Rats
  • Rats, Wistar
  • Semen Analysis
  • Spermatozoa / drug effects
  • Spermatozoa / metabolism*
  • Swimming*


  • Anabolic Agents
  • Antioxidants
  • Nandrolone
  • Nandrolone Decanoate
  • Melatonin