Molecular characterization of Streptococcus agalactiae isolates harboring small erm(T)-carrying plasmids

Antimicrob Agents Chemother. 2014 Nov;58(11):6928-30. doi: 10.1128/AAC.03855-14. Epub 2014 Aug 18.

Abstract

Among 1,827 group B Streptococcus (GBS) strains collected between 2006 and 2013 by the French National Reference Center for Streptococci, 490 (26.8%) strains were erythromycin resistant. The erm(T) resistance gene was found in six strains belonging to capsular polysaccharides Ia, III, and V and was carried by the same mobilizable plasmid, which could be efficiently transferred by mobilization to GBS and Enterococcus faecalis recipients, thus promoting a broad dissemination of erm(T).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Capsules / genetics
  • Bacterial Proteins / genetics*
  • Base Sequence
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Erythromycin / pharmacology*
  • Methyltransferases / genetics*
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Sequence Analysis, DNA
  • Serotyping
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / microbiology
  • Streptococcus agalactiae / drug effects*
  • Streptococcus agalactiae / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • capsular polysaccharide, streptoccal group B type V
  • Erythromycin
  • ErmTR protein, bacteria
  • Methyltransferases